Overview

Connecting Pharmacokinetics to Development Success

In vivo pharmacokinetic (PK) studies are essential for evaluating whether drug candidates possess appropriate pharmacokinetic characteristics for preclinical pharmacology and safety assessments. These studies generate critical data for determining human equivalent doses, no observed effect levels (NOELs), and PK/PD drivers. At VIMTA, we conduct routine pharmacokinetic studies using multiple routes of administration, including oral, sublingual, intravenous infusion, intravenous bolus, intragastric, intramuscular, subcutaneous, epicutaneous, transdermal, intravesical, intraperitoneal, intranasal, intratracheal, and intradermal.

Pharmacokinetic Capabilities

Bioavailability studies in mice, rats, rabbits, guinea pigs, and dogs using various routes of administration compared with intravenous infusion or bolus
Tissue distribution and uptake studies in mice and rats
Optimization of formulations and cassette dosing strategies for discovery projects
Long-term pharmacokinetic studies with the capacity to conduct multiple studies simultaneously

Ocular Biodistribution

Ocular tissue pharmacokinetic studies in rabbits using multiple routes of administration
Topical administration
Subconjunctival administration
ntravitreal administration
Intrastromal administration
Expertise in tissue homogenization for small tissue weights and sample volumes using specialized instrumentation

Dermal Absorption

Dermal absorption studies under occlusive, semi-occlusive, and non-occlusive conditions in rodents and non-rodents
Topical administration (per square centimeter)
Intradermal administration